ANALYSING MEDICAL IMAGING DATA STARTING WITH BLOOD PERFUSION

About Medical Imaging

ZiuZ is developing products to use its visual Intelligence capabilities to help hospitals analyze large amounts of medical imaging data and help surgeons to see things they could until now not see. The first product that comes out of these new product developments, is a Medical Device to help surgeons see and analyze blood perfusion.

ZiuZ and LIMIS Development have entered into a partnership to develop a medical imaging device designed to help prevent serious complications in colon cancer operations. The device provides surgeons with a real-time blood perfusion map of the blood flow during a colon operation to select the optimal site for the anastomosis, for the re-attachment of the colon stumps. The blood flow is measured using a technique called Laser Speckle Contrast Imaging (LSCI) where diffused coherent laser light produces a speckle pattern upon sub-surface blood flow.

Technology

Laser Speckle Contrast Imaging

Colon cancer is one of the most frequent forms of cancer for which different treatments exist. Often it is necessary to remove part of the colon and reattach the remaining parts by means of laparoscopic surgery. During this operation, there is a risk of one or both of the remaining parts being poorly perfused causing anastomotic leakage which is a major complication worldwide with occurrence rates ranging up to 13% and a mortality rate of around 10%. It occurs roughly 4 days post-surgery and often requires re-operation and prolonged hospitalization. Anastomotic leakage is multi-factorial, meaning that it is hard to determine the exact cause, however, the general consensus is that the state of perfusion at the site of the anastomosis is a major contributor. Currently, surgeons determine the state of microcirculation based on subjective measures of viability such as tissue colour and palpable motion or bleeding at the resected edges. PerfusiX is a medical device that provides surgeons with a real-time blood perfusion map of the blood flow during an operation of the colon to select the optimal site for the anastomosis. The blood flow is visualized using a technique called Laser Speckle Contrast Imaging (LSCI) where scattered coherent laser light produces a speckle pattern onto a CCD camera due to optical interference upon sub-surface blood flow.

Red blood cells1

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